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Article Dans Une Revue European Journal of Organic Chemistry Année : 2019

Heteromultifunctional Oxazolones as Versatile Linkers for Click Chemistry Reactions

Résumé

New oxazolone-based heteromultifunctional linkers were synthesized using a zinc-mediated double functionalization of nitriles as the key step. The orthogonality of the functional groups displayed by this original scaffold was demonstrated by conducting sequential or simultaneous multi-component reactions with amines (oxazolone ring opening), thiols (thiol-ene radical reaction) and azides (Cu-catalyzed azide–alkyne coupling), in respect to the concept of click chemistry.
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Dates et versions

hal-02380743 , version 1 (26-11-2019)

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Mathilde Pantin, Julien Caillé, Fabien Boeda, Laurent Fontaine, Morwenna Pearson-Long, et al.. Heteromultifunctional Oxazolones as Versatile Linkers for Click Chemistry Reactions. European Journal of Organic Chemistry, 2019, 2019 (44), pp.7359-7366. ⟨10.1002/ejoc.201901350⟩. ⟨hal-02380743⟩
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