Oxa-diketopiperazines: Access and Conformational Analysis of Potential Turn Inducers - Le Mans Université
Article Dans Une Revue ChemistrySelect Année : 2017

Oxa-diketopiperazines: Access and Conformational Analysis of Potential Turn Inducers

Résumé

An improvement of the 1,2,5‐oxadiazine‐3,6‐diones (Oxd) synthesis and reactivity is described in this paper. The methodology has been successfully applied to produce a library of this poorly studied scaffold, which can be considered as an oxa‐diketopiperazine (oxa‐DKP). Significantly, the first crystal structures of oxa‐DKP were obtained and compared to the diketopiperazine ring. Finally, a straightforward procedure concerning the coupling of various amino acids with oxa‐DKP heterocycles to afford original peptidomimetics was reported. The conformational analysis realized on di‐ and tripeptide analogs revealed that the oxa‐DKP skeleton exhibited remarkable β‐turn inducer properties.

Domaines

Chimie
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Dates et versions

hal-02313808 , version 1 (11-10-2019)

Identifiants

Citer

Mathéo Berthet, Aurélien Lebrun, Arnaud Martel, Thomas Cheviet, Jean Martinez, et al.. Oxa-diketopiperazines: Access and Conformational Analysis of Potential Turn Inducers. ChemistrySelect, 2017, 2 (21), pp.5824-5827. ⟨10.1002/slct.201701393⟩. ⟨hal-02313808⟩
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