Synthesis and glycosidase inhibitory activity of 1-amino-3,6-anhydro-1-deoxy-d-sorbitol derivatives - Le Mans Université Accéder directement au contenu
Article Dans Une Revue Bioorganic Chemistry Année : 2010

Synthesis and glycosidase inhibitory activity of 1-amino-3,6-anhydro-1-deoxy-d-sorbitol derivatives

Résumé

3,6-Anhydro-1-(aryl or alkylamino)-1-deoxy-d-sorbitol derivatives have been prepared in four steps from isosorbide, a by-product from the starch industry. The inhibitory activities of these new compounds have been evaluated towards 13 glycosidases. A first lead-compound was identified, which inhibited β-N-acetylglucosaminidase from bovine kidney (82% inhibition at 1 mM).

Dates et versions

hal-02132564 , version 1 (17-05-2019)

Identifiants

Citer

Stéphane Guillarme, Jean-Bernard Behr, Claudia Bello, Pierre Vogel, Christine Saluzzo. Synthesis and glycosidase inhibitory activity of 1-amino-3,6-anhydro-1-deoxy-d-sorbitol derivatives. Bioorganic Chemistry, 2010, 38 (2), pp.43-47. ⟨10.1016/j.bioorg.2009.12.002⟩. ⟨hal-02132564⟩
97 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More