Transposable elements and human cancer: A causal relationship? - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Biochimica et Biophysica Acta (BBA) - Reviews on Cancer Année : 2013

Transposable elements and human cancer: A causal relationship?

(1)
1
Benoît Chénais

Résumé

Transposable elements are present in almost all genomes including that of humans. These mobile DNA sequences are capable of invading genomes and their impact on genome evolution is substantial as they contribute to the genetic diversity of organisms. The mobility of transposable elements can cause deleterious mutations, gene disruption and chromosome rearrangements that may lead to several pathologies including cancer. This mini-review aims to give a brief overview of the relationship that transposons and retrotransposons may have in the genetic cause of human cancer onset, or conversely creating protection against cancer. Finally, the cause of TE mobility may also be the cancer cell environment itself.
Fichier principal
Vignette du fichier
TE cancer_bba_preprint.pdf (428.27 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01906235 , version 1 (26-10-2018)

Identifiants

Citer

Benoît Chénais. Transposable elements and human cancer: A causal relationship?. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2013, 1835 (1), pp.28 - 35. ⟨10.1016/j.bbcan.2012.09.001⟩. ⟨hal-01906235⟩
51 Consultations
419 Téléchargements

Altmetric

Partager

Gmail Facebook Twitter LinkedIn More