Efficient antimicrobial activity and reduced toxicity of 1-dodecyl-3-methylimidazolium tetrafluoroborate ionic liquid/β-cyclodextrin complex - Le Mans Université Accéder directement au contenu
Article Dans Une Revue Chemical Engineering Journal Année : 2016

Efficient antimicrobial activity and reduced toxicity of 1-dodecyl-3-methylimidazolium tetrafluoroborate ionic liquid/β-cyclodextrin complex

Résumé

Water immiscible ionic liquid 1-dodecyl-3-methylimidazolium tetrafluoroborate (DMIM-BF4) and its inclusion complex with β-cyclodextrin (β-CD) in molar ratio 1:1 have been synthesized. The formation of DMIM-BF4/β-CD complex was confirmed by FT-IR analysis, 1H NMR analysis, and differential scanning calorimetry data. Our results indicate that the aliphatic tail of DMIM-BF4 is included into β-CD inner cavity whereas imidazolium ring is located outside the torus. Moreover, the weak interaction between polar components of ionic liquid and hydrophilic outer surface of β-CD has also been detected. The standard agar disk diffusion method was performed to evaluate antimicrobial efficiency of the obtained compounds against Staphylococcus aureus (ATCC-25923), Escherichia coli (ATCC-25922) and Pseudomonas aeruginosa (ATCC-27853), Candida albicans (M 885 ATCC 10231) and its clinical isolate test-cultures. It has been found that both DMIM-BF4 and DMIM-BF4/β-CD complex possess high antimicrobial activity as revealed by similar zone inhibition values against all tested microorganisms. The acute toxicity studies on Danio rerio (zebrafish) model organism showed that the pure ionic liquid DMIM-BF4 is slightly toxic compound having LD50 value of 7 mg/L, whereas DMIM-BF4/β-CD complex has considerably reduced toxicity (LD50 = 100 mg/L) and therefore have potentially wider application areas.
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Dates et versions

hal-01905100 , version 1 (25-10-2018)

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Diana Hodyna, Jean-François Bardeau, Larisa Metelytsia, Sergii Riabov, Larisa Kobrina, et al.. Efficient antimicrobial activity and reduced toxicity of 1-dodecyl-3-methylimidazolium tetrafluoroborate ionic liquid/β-cyclodextrin complex. Chemical Engineering Journal, 2016, 284, pp.1136-1145. ⟨10.1016/j.cej.2015.09.041⟩. ⟨hal-01905100⟩
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