Antisense oligonucleotides Dystrophie Myotonique Alternative splicing Intermediate filament Dynamin 2 Hypoxia Centronuclear myopathy RNA interference Motoneuron Neuron Gene Therapy GSK3␤ Glucocorticoid-receptor Fibrosis Duchenne muscular dystrophy Therapy Trinucleotide repeat expansion Animals Mouse models Brain CMS Myotonic Dystrophy Autophagy CRISPRi Glial cells Exercise Heart Acetylcholinesterase deficiency Gene therapy Brain dysfunction Myotonic dystrophy Myelin GABA CONGENITAL MYATHENIC SYNDROME Oligodendrocytes Mice Thérapie génique Exercice In vivo Dystrophin Dystrophie myotonique Myostatin Myotonic dystrophy type 1 AAV Knockout KNOCKOUT MICE Heart failure Long read sequencing Glutamate CTG repeat instability Myotonic Dystrophy Type 1 Astrocytes Gene editing Cytoskeleton CRISPR/Cas9 Cell culture model MBNL CTG repeats Endurance training ARN Transcriptomics Transgenic mouse DMPK Transgenic mouse model CTG repeat contractions Expression DMSXL mice Skeletal muscle Diaphragm Myotonic dystrophy mouse models Astrocyte Central nervous system Acetylcholinesterase knockout mouse RNA biology Maximal force Oligodendrocyte Mouse model Humans Dilated cardiomyopathy Cell model PCR Desmin Antisense oligonucleotide ACETYLCHOLINESTERASE RNA splicing BIOLOGIE MOLECULAIRE Muscular dystrophy Cell penetrating peptide Quantitative microdialysis DM1 Acute coronary syndrome Muscle Trinucleotide Repeat Expansion Cardiac muscle Myotonic Dystrophy type 1 PacBio Genotype phenotype correlation Male Glucocorticoids Aging