Hydrogen hydrates exhibit a rich phase diagram influenced by both pressure and temperature, with the so-called C2 phase emerging prominently above 2.5 GPa. In this phase, hydrogen molecules are densely packed within a cubic ice-like lattice and the interaction with the surrounding water molecules profoundly affects their quantum rotational dynamics. Herein, we delve into this intricate interplay by directly solving the Schro ̈dinger’s equation for a quantum H2 rotor in the C2 crystal field at finite temperature, generated through Density Functional Theory. Our calculations reveal a giant energy splitting relative to the magnetic quantum number of ±3.2 meV for l = 1. Employing inelastic neutron scattering, we experimentally measure the energy levels of H2 within the C2 phase at 6.0 and 3.4 GPa and low temperatures, finding good agreement with our theoretical predictions. These findings underscore the pivotal role of hydrogen–water interactions in dictating the rotational behavior of the hydrogen molecules within the C2 phase and indicate heightened van der Waals interactions compared to other hydrogen hydrates.