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Journal Articles Anaesthesia Critical Care & Pain Medicine Year : 2022

Guidelines for the management of patients with severe acute pancreatitis, 2021

Marc Garnier
  • Function : Author
Louis Buscail
Jean-Baptiste Chevaux
  • Function : Author
Lucie Darrivere
  • Function : Author
Matthieu Jabaudon
Olivier Joannes-Boyau
Yoann Launey
  • Function : Author
Eric Levesque
Philippe Levy
  • Function : Author
Laurent Muller
  • Function : Author
Claire Roger
  • Function : Author
Philippe Seguin
  • Function : Author
Geoffroy Vanbiervliet
  • Function : Author


Objective: To provide guidelines for the management of the intensive care patient with severe acute pancreatitis.Design: A consensus committee of 22 experts was convened. A formal conflict-of-interest (COI) policy was developed at the beginning of the process and enforced throughout. The entire guideline construction process was conducted independently of any industrial funding (i.e. pharmaceutical, medical devices). The authors were required to follow the rules of the Grading of Recommendations Assessment, Development and Evaluation (GRADE®) system to guide assessment of quality of evidence. The potential drawbacks of making strong recommendations in the presence of low-quality evidence were emphasised.Methods: The most recent SFAR and SNFGE guidelines on the management of the patient with severe pancreatitis were published in 2001. The literature now is sufficient for an update. The committee studied 14 questions within 3 fields. Each question was formulated in a PICO (Patients Intervention Comparison Outcome) format and the relevant evidence profiles were produced. The literature review and recommendations were made according to the GRADE® methodology.Results: The experts' synthesis work and their application of the GRADE® method resulted in 24 recommendations. Among the formalised recommendations, 8 have high levels of evidence (GRADE 1+/-) and 12 have moderate levels of evidence (GRADE 2+/-). For 4 recommendations, the GRADE method could not be applied, resulting in expert opinions. Four questions did not find any response in the literature. After one round of scoring, strong agreement was reached for all the recommendations.Conclusions: There was strong agreement among experts for 24 recommendations to improve practices for the management of intensive care patients with severe acute pancreatitis.
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Dates and versions

hal-03683080 , version 1 (31-05-2022)



Samir Jaber, Marc Garnier, Karim Asehnoune, Fanny Bounes, Louis Buscail, et al.. Guidelines for the management of patients with severe acute pancreatitis, 2021. Anaesthesia Critical Care & Pain Medicine, 2022, 41 (3), pp.101060. ⟨10.1016/j.accpm.2022.101060⟩. ⟨hal-03683080⟩
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